Evaluating the causal association between microRNAs and amyotrophic lateral sclerosis.
Yahui ZhuMao LiZhengqing HeXinyuan PangRongrong DuWenxiu YuJinghong ZhangJiongming BaiJiao WangXu-Sheng HuangPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
We suggested that higher levels of hsa-miR-27b-3p and hsa-miR-139-5p had protective effects on ALS, whereas higher levels of hsa-miR-152-3p might act as a risk factor for ALS. The analytical framework presented in this study helps to understand the role of miRNAs in the development of ALS and to identify the biomarkers for ALS risk.