Genomic Profiling of Lung Adenocarcinoma in Never-Smokers.
Siddhartha DevarakondaYize LiFernanda Martins RodriguesSumithra SankararamanHumam KadaraChandra GoparajuIrena LancKymberlie PepinSaiama N WaqarDaniel MorgenszternJeffrey P WardAshiq MasoodRobert FultonLucinda FultonMichael A GilletteShankha SatpathySteven A CarrIgnacio WistubaHarvey PassRichard K WilsonLi DingRamaswamy GovindanPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
In this comprehensive genomic and transcriptome analysis of never-smoker LUADs, we observed a potential role for germline variants in DNA repair genes and passive exposure to cigarette smoke in the pathogenesis of a subset of never-smoker LUADs. Our findings also show that clinically actionable driver alterations are highly prevalent in never-smoker LUADs, highlighting the need for obtaining biopsies with adequate cellularity for clinical genomic testing in these patients.