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Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.

Clément RaynaudWassim DaherFrançoise Roquet-BanèresMatt D JohansenJozef StecOluseye K OnajoleDiane OrdwayAlan P KozikowskiLaurent Kremer
Published in: Antimicrobial agents and chemotherapy (2020)
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
Keyphrases
  • mycobacterium tuberculosis
  • risk assessment
  • human health
  • gram negative