Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort.
Micol AvenaliRoberta ZangagliaGiada CuconatoIlaria PalmieriAlberto AlbaneseCarlo Alberto ArtusiMarco BozzaliGiovanna Calandra-BuonauraFrancesco CavallieriRoberto CiliaAntoniangela CoccoFilippo CogiamanianFabiana ColucciPietro CortelliAlessio Di FonzoRoberto EleopraGiulia GianniniAlberto ImarisioGabriele ImbalzanoClaudia LeddaLeonardo LopianoMaria Chiara MalagutiFrancesca MameliRaffaella MinardiPierfrancesco MitrottiEdoardo MonfriniFrancesca SpagnoloCristina TassorelliFrancesca ValentinoFranco ValzaniaClaudio PacchettiEnza Maria Valentenull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2023)
variants in a large Italian DBS-PD cohort supported the role of DBS surgery as a valid therapeutic strategy in GBA-PD, with long-term benefit on motor performance and ICD. Despite the selective worsening of cognitive scores since 3 years post-DBS, the majority of GBA-PD had not developed dementia at 5-year follow-up.