Lipopolysaccharide-induced DNA damage response activates nuclear factor κB signalling pathway via GATA4 in dental pulp cells.

Weiwei Qiao Y HuangZ BianX SunX WangQ GaoY PengL Meng

Published in: International endodontic journal (2019)

Lipopolysaccharide-induced DSBs activated the NF-κB signalling pathway in hDPCs, and GATA4 acts as a positive moderator of the progress. The involvement of GATA4 in this pathology may serve as a therapeutic target in pulpitis.

Keyphrases

lipopolysaccharide induced
nuclear factor
dna damage response
inflammatory response
toll like receptor
transcription factor
induced apoptosis
lps induced
signaling pathway
cell cycle arrest
oxidative stress
cell proliferation