Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation.

Huanhuan LiuAnupama BinoySiqi RenThomas C MartinoAnna E MillerCraig R G WillisShivakumar R VeerabhadraiahAbhijit SukulJoanna BonsJacob P RoseBirgit SchillingMichael J JurynecShouan Zhu

Published in: bioRxiv : the preprint server for biology (2024)

We found that Sirt5 mediated MaK is an important regulator of chondrocyte cellular metabolism and dysregulation of Sirt5-MaK could be an important mechanism underlying aging and obesity associated OA development.

Keyphrases

oxidative stress
ischemia reperfusion injury
metabolic syndrome
insulin resistance
knee osteoarthritis
type diabetes
rheumatoid arthritis
weight loss
amino acid
transcription factor
weight gain
small molecule
adipose tissue
high fat diet induced