Genomic ancestry as a risk factor for diabetic retinopathy in patients with type 1 diabetes from an admixed population: a nested case-control study in Brazil.
Deborah Conte SantosLaura Gomes Nunes de MeloMarcela Haas PizarroBianca S V BarrosCarlos Antonio NegratoLuís Cristóvão PortoDayse A SilvaKarla Rezende Guerra DrummondLuiza Harcar MunizTessa Cerqueria Lemos MattosAndré Araújo PinheiroFelipe MallmannFranz Schubert Lopes LealFernando Korn MalerbiPaulo Henrique MoralesMarília Brito GomesPublished in: Acta diabetologica (2020)
Genomic ancestry, as well as clinical variables such as hypertension, impaired glomerular filtration rate and poor diabetes control (HbA1c), was important risk factor for the development of severe diabetic retinopathy. Further studies are needed, especially in highly admixed populations, to better understand the role of genomic ancestry and possible genes that might be associated with the development and/or progression of diabetic retinopathy.