Histopathological myocardial changes in patients with severe aortic stenosis referred for surgical valve replacement: a cardiac magnetic resonance correlation study.
João AbecasisPedro LopesSergio MaltesRita Reis SantosAntónio FerreiraRegina RibeirasMaria João AndradeMiguel Sousa UvaVictor GilAna FélixSancia RamosNuno CardimPublished in: European heart journal. Cardiovascular Imaging (2024)
Patients with severe symptomatic AS referred for surgical AVR have unspecific histological myocardial changes, including signs of cardiomyocyte ischaemic insult. ECM remodelling is ongoing, with MF heterogeneity. These features may be recognized by comprehensive CMR protocols. However, no single CMR parameter captures the burden of MF and histological myocardial changes in this setting.
Keyphrases
- left ventricular
- aortic stenosis
- aortic valve replacement
- magnetic resonance
- transcatheter aortic valve implantation
- aortic valve
- transcatheter aortic valve replacement
- ejection fraction
- mitral valve
- heart failure
- early onset
- coronary artery disease
- drug induced
- magnetic resonance imaging
- extracellular matrix
- endothelial cells
- risk factors
- contrast enhanced
- high glucose