Transcriptional profiling of primary endometrial epithelial cells following acute HIV-1 exposure reveals gene signatures related to innate immunity.
Muhammad Atif ZahoorMatthew William WoodsSara DizzellAisha NazliKristen M MuellerPhilip V NguyenChris P VerschoorCharu KaushicPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
The gene expression signature of endometrial GECs indicates that the response of these cells may be key to determining host susceptibility to HIV-1 and that sex hormones modulate these interactions. This study allows us to explore possible mechanisms that explain the hormone-mediated fluctuation of HIV-1 susceptibility in women.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- gene expression
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- genome wide
- endometrial cancer
- type diabetes
- cell cycle arrest
- adipose tissue
- transcription factor
- cell death
- intensive care unit
- single cell
- acute respiratory distress syndrome
- skeletal muscle
- mechanical ventilation
- genome wide analysis