An open resource for transdiagnostic research in pediatric mental health and learning disorders.
Lindsay M AlexanderJasmine EscaleraLei AiCharissa AndreottiKarina FebreAlexander MangoneNatan Vega-PotlerNicolas LangerAlexis AlexanderMeagan KovacsShannon LitkeBridget O'HaganJennifer AndersenBatya BronsteinAnastasia BuiMarijayne BusheyHenry ButlerVictoria CastagnaNicolas CamachoElisha ChanDanielle CiteraJon C ClucasSamantha CohenSarah DufekMegan EavesBrian FraderaJudith GardnerNatalie Grant-VillegasGabriella GreenCamille GregoryEmily HartShana HarrisMegan HortonDanielle KahnKatherine KabotyanskiBernard KarmelSimon P KellyKayla KleinmanBonhwang KooEliza KramerElizabeth LennonCatherine LordGinny MantelloAmy MargolisKathleen R MerikangasJudith MilhamGiuseppe MinnitiRebecca NeuhausAlexandra LevineYael OsmanLucas C ParraKen R PughAmy RacanelloAnita RestrepoTian SaltzmanBatya SeptimusRussell TobeRachel WaltzAnna WilliamsAnna YeoFrancisco X CastellanosArno KleinTomas PausBennett L LeventhalRichard C CraddockHarold S KoplewiczMichael P MilhamPublished in: Scientific data (2017)
Technological and methodological innovations are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, ambitions to achieve clinically useful tools to assist in the diagnosis and management of mental health and learning disorders are gaining momentum. To this end, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. The Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank of data from 10,000 New York area participants (ages 5-21). The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle phenotypes, as well as multimodal brain imaging (resting and naturalistic viewing fMRI, diffusion MRI, morphometric MRI), electroencephalography, eye-tracking, voice and video recordings, genetics and actigraphy. Here, we present the rationale, design and implementation of HBN protocols. We describe the first data release (n=664) and the potential of the biobank to advance related areas (e.g., biophysical modeling, voice analysis).
Keyphrases
- mental health
- resting state
- electronic health record
- functional connectivity
- magnetic resonance imaging
- mental illness
- big data
- contrast enhanced
- quality improvement
- high resolution
- white matter
- pain management
- metabolic syndrome
- clinical trial
- cardiovascular disease
- computed tomography
- primary care
- neoadjuvant chemotherapy
- heart rate
- data analysis
- machine learning
- squamous cell carcinoma
- climate change
- risk assessment
- subarachnoid hemorrhage
- mass spectrometry
- human health
- cerebral ischemia
- network analysis
- fluorescence imaging