Tannic acid alleviates ETEC K88-induced intestinal damage through regulating the p62-keap1-Nrf2 and TLR4-NF-κB-NLRP3 pathway in IPEC-J2 cells.
Wenhui LiuKangkang GuoPublished in: Journal of the science of food and agriculture (2024)
The present study showed that TA reduced the diarrhea rate of weaned piglets by restoring the intestinal mucosal mechanical barrier function, alleviating oxidative stress and inflammation. The underlying mechanism was achieved by modulating the p62-keap1-Nrf2 and TLR4-NF-κB-NLRP3 pathway. © 2024 Society of Chemical Industry.
Keyphrases
- oxidative stress
- induced apoptosis
- diabetic rats
- toll like receptor
- signaling pathway
- inflammatory response
- ischemia reperfusion injury
- dna damage
- nuclear factor
- immune response
- lps induced
- protein protein
- cell cycle arrest
- pi k akt
- mouse model
- clostridium difficile
- endoplasmic reticulum stress
- drug induced
- endothelial cells
- heat shock
- irritable bowel syndrome