Dual Nickel/Photoredox-Catalyzed Asymmetric Carbamoylation of Benzylic C(sp 3 )-H Bonds.

Radical-mediated Hydrogen Atom Abstraction of Csp 3 -H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α-aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel-catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.