Systematic expression analysis of plasticity-related genes in mouse brain development brings PRG4 into play.
Isabel GrossTabea TschigorAngelina L SalmanFan YangJiankai LuoDanara VonkMark S HippJohn NeidhardtAnja Ursula BräuerPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
We showed PRG4 to be highly expressed in the developing and the adult brain, suggesting that it is of vital importance for normal brain function. Despite its similarities to other family members, it seems not to be involved in changes of cell morphology; instead, it is more likely to be associated with intracellular signaling.