MicroRNA-25 Protects Smooth Muscle Cells against Corticosterone-Induced Apoptosis.

Bin ZhangGaoxing ZhangTianlu WeiZhen YangWenfeng TanZiqing MoJinxue LiuDong LiYidong WeiLukun ZhangKeith A WebsterJianqin Wei

Published in: Oxidative medicine and cellular longevity (2019)

MicroRNA-25 blocks corticosterone-induced VSMC apoptosis by targeting MOAP1 and the p70S6k pathway. Therapeutic manipulation of miR-25 may reduce atherosclerosis and unstable plaque formation associated with chronic stress.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
diabetic rats
signaling pathway
cell proliferation
long non coding rna
high glucose
cardiovascular disease
drug induced
coronary artery disease
long noncoding rna
cell death
heat stress