Cu2O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection.
Kuang-Wen TsengYu-Ping HsiaoChun-Ping JenTsung-Shun ChangHsiang-Chen WangPublished in: Sensors (Basel, Switzerland) (2020)
A highly sensitive photoelectrochemical (PEC) biosensor without external bias was developed in this study. The biosensor was configured with a p-Cu2O and n-ZnO heterostructure. Hexamethylenetetramine (HMTA) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was used to improve the crystal structure of Cu2O and ZnO and reduce the defects in the Cu2O/ZnO interface. This fabrication method provided the highly crystallized Cu2O/ZnO structure with excellent electrical property and photoresponse in visible light. The structure was applied to a biosensor for detecting two different cancerous levels of esophageal cells, namely, OE21 and OE21-1, with a high gain in photocurrent (5.8 and 6.2 times, respectively) and a low detection limit (3000 cells in 50 μL). We believe that such a p-n heterojunction PEC biosensor could advance biosensor development and provide a promising candidate for biomedical applications.
Keyphrases
- visible light
- quantum dots
- label free
- sensitive detection
- gold nanoparticles
- reduced graphene oxide
- induced apoptosis
- loop mediated isothermal amplification
- aqueous solution
- room temperature
- cell cycle arrest
- metal organic framework
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- cell proliferation
- fluorescent probe
- molecularly imprinted