A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.

Annalisa AddanteWilfred RaymondIrina GitlinAnnabelle CharbitXavier OrainAaron Wolfe SchefflerAditi KuppeJulia DuerrMaria DaniltchenkoMarika DrescherSimon Y GraeberAnne-Marie HealyStefan OscarsonJohn V FahyMarcus Alexander Mall

Published in: The European respiratory journal (2023)

MUC-031 is a potent and fast acting mucolytic that decreases airway mucus plugging, lessens airway inflammation, and improves survival in βENaC-Tg mice. These data provide rationale for human trials of MUC-031 in muco-obstructive lung diseases.

Keyphrases

endothelial cells
electronic health record
high fat diet induced
big data
clinical trial
induced pluripotent stem cells
insulin resistance
machine learning
adipose tissue
wild type
skeletal muscle
anti inflammatory
data analysis
smoking cessation