Excessive mechanical stress induced temporomandibular joint osteoarthritis via osteoclasts-mediated osteogenic differentiation of BMSCs.

Lingzhi WangYihong TianMeixi LiuZijing HeXiao YanXiao YuanQiang Zhang

Published in: Journal of oral rehabilitation (2022)

Our results proved that EMS led to TMJ OA, in which upregulated p-ERK1/2 in osteoclasts was mechanosensitive and facilitated the osteogenic differentiation of BMSCs.

Keyphrases

stress induced
bone loss
knee osteoarthritis
signaling pathway
rheumatoid arthritis
cell proliferation
weight gain
pi k akt