New Acetylenic Acids and Derivatives from the Edible Mushroom Craterellus lutescens (Cantharellaceae).
Ying HuangShuai-Bing ZhangHe-Ping ChenZhen-Zhu ZhaoZhong-Yu ZhouZheng-Hui LiTao FengJi-Kai LiuPublished in: Journal of agricultural and food chemistry (2017)
Thirteen new acetylenic acids and their derivatives, craterellynes G-Q (1, 2, 4-10, 12, 13), 9-epi-craterellyne H (3), and 14-O-ethyl-craterellyne O (11), were isolated from the fruiting bodies of edible mushrooms Craterellus lutescens. The structures of these compounds were identified by various spectroscopic and chemical means. The stereoconfigurations of 1-13 were elucidated by the combination of acetonide formation, J-based configuration analysis, and modified Mosher's method. Craterellyne I exhibited cytotoxicities against human cancer strains and inhibition of nitric oxide (NO) production, as well as weak antimicrobial activity against Candida albicans.
Keyphrases
- candida albicans
- nitric oxide
- biofilm formation
- endothelial cells
- papillary thyroid
- escherichia coli
- molecular docking
- squamous cell
- high resolution
- structure activity relationship
- induced pluripotent stem cells
- squamous cell carcinoma
- mass spectrometry
- pseudomonas aeruginosa
- cystic fibrosis
- young adults
- data analysis