Prevalence of CYP2C19 and ITGB3 polymorphisms among Bangladeshi patients who underwent percutaneous coronary intervention.
Md Rabiul IslamTasnova Tasnim NovaNam MomenuzzamanSikder Nahidul Islam RabbiIshrat JahanThomas BinderMohammad Safiqul IslamAbul HasnatZabun NaharPublished in: SAGE open medicine (2021)
In the present study, we observed a high prevalence of genetic polymorphisms of CYP2C19 and ITGB3 genes. Therefore, we recommend genotyping of CVD patients before prescribing clopidogrel or aspirin to prevent coagulation. Based on the genotyping study, the adjustment of doses or alternative generics might require to avoid therapeutic failure or toxicity in some cases.
Keyphrases
- end stage renal disease
- percutaneous coronary intervention
- ejection fraction
- newly diagnosed
- chronic kidney disease
- acute coronary syndrome
- genome wide
- low dose
- primary care
- coronary artery disease
- type diabetes
- cardiovascular disease
- high throughput
- acute myocardial infarction
- patient reported outcomes
- emergency department
- heart failure
- cardiovascular events
- single cell
- adverse drug
- coronary artery bypass