Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development.

Jiajie Tu Weile ChenWei HuangXinming WangYilong FangXuming WuHuiru ZhangChong LiuXuewen TanXiangling ZhuHuihui WangDafei HanYizhao ChenAnqi WangYuanyuan ZhouZimeng XueHui XueShangxue YanLingling ZhangZhenbao LiChunlan YangYujie DengShihao ZhangChen ZhuWei Wei

Published in: Annals of the rheumatic diseases (2024)

These results support that the PU.1-IL-9 axis forms a positive loop in Th9 dysregulation of RA. Targeting this signalling axis presents a potential target approach for treating RA.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
interstitial lung disease
transcription factor
systemic lupus erythematosus
cancer therapy
systemic sclerosis
human health