Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy.
Stanislav KeranovSaskia HaenJulia VietheerWiebke RutsatzJan-Sebastian WolterSteffen D KriechbaumBeatrice von JeinsenPascal BauerKhodr TelloManuel RichterOliver DörrAndreas J RiethHolger NefChristian W HammChristoph LiebetrauAndreas RolfSteffen D KriechbaumPublished in: Diagnostics (Basel, Switzerland) (2021)
The main aim of this study was to assess the prognostic utility of TAPSE/PASP as an echocardiographic parameter of maladaptive RV remodeling in cardiomyopathy patients using cardiac magnetic resonance (CMR) imaging. Furthermore, we sought to compare TAPSE/PASP to TAPSE. The association of the echocardiographic parameters TAPSE/PASP and TAPSE with CMR parameters of RV and LV remodeling was evaluated in 111 patients with ischemic and non-ischemic cardiomyopathy and cut-off values for maladaptive RV remodeling were defined. In a second step, the prognostic value of TAPSE/PASP and its cut-off value were analyzed regarding mortality in a validation cohort consisting of 221 patients with ischemic and non-ischemic cardiomyopathy. A low TAPSE/PASP (<0.38 mm/mmHg) and TAPSE (<16 mm) were associated with a lower RVEF and a long-axis RV global longitudinal strain (GLS) as well as higher RVESVI, RVEDVI and NT-proBNP. A low TAPSE/PASP, but not TAPSE, was associated with a lower LVEF and long-axis LV GLS, and a higher LVESVI, LVEDVI and T1 relaxation time at the interventricular septum and the RV insertion points. Furthermore, in the validation cohort, low TAPSE/PASP was associated with a higher mortality and TAPSE/PASP was an independent predictor of mortality. TAPSE/PASP is a predictor of maladaptive RV and LV remodeling associated with poor outcomes in cardiomyopathy patients.
Keyphrases
- mycobacterium tuberculosis
- heart failure
- left ventricular
- pulmonary artery
- magnetic resonance
- ejection fraction
- pulmonary hypertension
- coronary artery
- ischemia reperfusion injury
- blood pressure
- newly diagnosed
- mitral valve
- prognostic factors
- cardiovascular events
- cerebral ischemia
- pulmonary arterial hypertension
- high resolution
- type diabetes
- coronary artery disease
- aortic valve
- left atrial
- brain injury
- insulin resistance
- contrast enhanced