DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice.
Ami SotokawauchiTakanori MatsuiYuichiro HigashimotoYuri NishinoYoshinori KogaMinoru YagiSho-Ichi YamagishiPublished in: Diabetes & vascular disease research (2021)
Our present results suggest that RAGE-aptamer could inhibit tubular injury in obese type 2 diabetic mice partly by suppressing the AGE-RAGE-oxidative stress axis and improving insulin resistance.
Keyphrases
- oxidative stress
- insulin resistance
- adipose tissue
- gold nanoparticles
- metabolic syndrome
- sensitive detection
- magnetic nanoparticles
- type diabetes
- high glucose
- circulating tumor
- label free
- high fat diet
- dna damage
- signaling pathway
- diabetic rats
- single molecule
- induced apoptosis
- cell free
- ischemia reperfusion injury
- skeletal muscle
- obese patients
- endothelial cells
- high fat diet induced
- nucleic acid
- heat shock
- binding protein
- heat shock protein