Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.

Jih-Yang KoFeng-Sheng WangWei-Shiung LianFu-Shine YangJeng-Wei ChenPo-Hua HuangChin-Yi LiaoShu-Jui Kuo

Published in: Molecular medicine (Cambridge, Mass.) (2024)

Our study elucidates that DKK1-AS has the capability to enhance bone mechanical properties, restore the transcription of osteogenic genes, promote osteogenesis, and inhibit osteoclastogenesis in OI mice.

Keyphrases

bone regeneration
bone loss
bone mineral density
mesenchymal stem cells
soft tissue
bone marrow
transcription factor
genome wide
high fat diet induced
gene expression
dna methylation
adipose tissue
insulin resistance
inflammatory response