Azobenzene-isoxazoline as photopharmacological ligand for optical control of insect GABA receptor and behavior.

Azobenzene-Isoxazoline as photopharmacological ligand was synthesized and evaluated for optical control of insect GABARs and behavior for the first time. ABF03 completed the differential regulation of cockroach neurons and the real-time reversible regulation of insect behavior. The establishment of photochromic ligands provides a new strategy for basic and convenience-oriented research on GABARs in invertebrates.