Vitamin D supplementation modulates autophagy in the pristane-induced lupus model.

Manuela Dos SantosJordana Miranda de Souza SilvaBárbara Jonson BartikoskiEduarda Correa FreitasAmanda BusattoRafaela Cavalheiro do Espírito SantoOdirlei Andre MonticieloRicardo Machado Xavier

Published in: Advances in rheumatology (London, England) (2022)

Changes in skeletal muscle in PIL model happen before CSA reduction, possibly due to autophagy degradation, and treatment with Vitamin D has a impact on physical function by decreasing muscle strength and time of fatigue.. Vitamin D supplementation has a potential role modulating physical parameters and signaling pathways in muscle during pristane-induced lupus model.

Keyphrases

skeletal muscle
signaling pathway
systemic lupus erythematosus
cell death
diabetic rats
high glucose
oxidative stress
endoplasmic reticulum stress
disease activity
mental health
insulin resistance
rheumatoid arthritis
pi k akt
metabolic syndrome
depressive symptoms
smoking cessation