Somatic SNCA Copy Number Variants in Multiple System Atrophy Are Related to Pathology and Inclusions.

Monica Emili Garcia-SeguraDiego Pérez-Rodríguez Darren Chambers Zane T Jaunmuktane Christos Proukakis

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

The correlation between SNCA CNVs and pathology (at a regional level) and inclusions (at a single-cell level) suggests a role for somatic SNCA CNVs in MSA pathogenesis. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

copy number
mitochondrial dna
single cell
genome wide
dna methylation
rna seq
high throughput