Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.

Suna Onngut-GumuscuWei-Min ChenCatherine C RobertsonJessica K BonnieEmily FarberZhennan ZhuJorge R OksenbergSteven R BrantS Louis BridgesJeffrey C EdbergRobert P KimberlyPeter K GregersenMarian J RewersAndrea K SteckMary H BlackDana M Dabelea Catherine PihokerMark A AtkinsonLynne E WagenknechtJasmin DiversRonny A Bellnull nullnull nullHenry A ErlichPatrick J Concannon Stephen S Rich

Published in: Diabetes care (2019)

Genetic risk of type 1 diabetes includes ancestry-specific, disease-associated variants. The GRS developed here provides improved prediction of type 1 diabetes in African-ancestry subjects and a means to identify groups of individuals who would benefit from immune monitoring for early detection of islet autoimmunity.

Keyphrases

type diabetes
genome wide association study
copy number
glycemic control
genome wide
cardiovascular disease
insulin resistance
gene expression
metabolic syndrome