Thrombospondin 2 is a key determinant of fibrogenesis in non-alcoholic fatty liver disease.

Takefumi KimuraTakanobu IwadareShun-Ichi WakabayashiSeema KuldeepTomoyuki NakajimaTomoo YamazakiDaiki AomuraHamim ZafarMai IwayaSatoru JoshitaTakeshi UeharaSai P PydiNaoki TanakaTakeji Umemura
Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)
THBS2/TSP2 is highly expressed in HSCs and plays a role in regulating fibrogenesis in NAFLD patients. THBS2/TSP2 may therefore represent a potential target for anti-fibrotic therapy in NAFLD.