Thrombospondin 2 is a key determinant of fibrogenesis in non-alcoholic fatty liver disease.

Takefumi KimuraTakanobu IwadareShun-Ichi WakabayashiSeema KuldeepTomoyuki NakajimaTomoo YamazakiDaiki AomuraHamim ZafarMai IwayaSatoru JoshitaTakeshi UeharaSai P PydiNaoki TanakaTakeji Umemura

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

THBS2/TSP2 is highly expressed in HSCs and plays a role in regulating fibrogenesis in NAFLD patients. THBS2/TSP2 may therefore represent a potential target for anti-fibrotic therapy in NAFLD.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
stem cells
idiopathic pulmonary fibrosis
patient reported outcomes
patient reported
pulmonary fibrosis