Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499.
Kazunari SakaiMasato IwatsukiMasato IizukaYukihiro AsamiKenichi NonakaRokuro MasumaMami TakizawaTakuji NakashimaToshiyuki TokiwaKazuro ShiomiSatoshi ŌmuraPublished in: The Journal of antibiotics (2021)
An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.