Effect of Intensive Blood Pressure Control on Troponin and Natriuretic Peptide Levels: Findings From SPRINT.
Jarett D BerryHaiying ChenVijay NambiWalter T AmbrosiusSimon B AscherMichael G ShlipakJoachim H IxRajesh GuptaAnthony A KilleenRobert D TotoDalane W KitzmanChristie M BallantyneJames A de LemosPublished in: Circulation (2022)
Intensive SBP lowering increased hs-cTnT, mediated by the effect of SBP lowering on reduced kidney filtration. In contrast, intensive SBP lowering decreased NT-proBNP, a finding that was explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing variation in cardiac biomarkers and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.