Reversing the Genomic, Epigenetic, and Triple-Negative Breast Cancer-Enhancing Effects of Obesity.

Laura W Bowers Steven S Doerstling Meghana G Shamsunder Claire G Lineberger Emily L Rossi Stephanie A Montgomery Michael Francis Coleman Weida Gong Joel S Parker Anthony Howell Michelle N Harvie Stephen D Hursting

Published in: Cancer prevention research (Philadelphia, Pa.) (2022)

Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC). Given rising global rates of obesity and TNBC, strategies to reduce the burden of obesity-driven TNBC are urgently needed. We report the genomic, epigenetic, and procancer effects of obesity are reversible by various calorie restriction regimens.

Keyphrases

weight loss
insulin resistance
metabolic syndrome
high fat diet induced
type diabetes
weight gain
adipose tissue
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