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Antimicrobial peptide-fibrin glue mixture for treatment of methicillin-resistant Staphylococcus aureus -infected wounds.

Mehran BahreiniMehrdad Moosazadeh MoghaddamMasoud GhorbaniMohammad Reza NouraniReza Mirnejad
Published in: Therapeutic delivery (2024)
Aim: This study was conducted to investigate the effect of fibrin glue-CM11 antibacterial peptide mixture (FG-P) on the healing of infected wounds in vivo . Materials & methods: We formulated a mixture of FG-P and evaluated its antimicrobial activity in vitro against multidrug-resistant (MDR) bacteria involved in wound infection as well as its healing effect on wound infected by methicillin-resistant S. aureus (MRSA) in vivo . Results: The peptide had an MIC of 8 μg/ml against all bacteria isolates. Growth inhibition zones were evident for FG-P compared with FG. The in vivo study showed that the FG-P could be significantly effective in healing the MRSA-infected wound. Conclusion: The use of FG-P mixture is a very suitable option for treating infected wounds.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • staphylococcus aureus
  • multidrug resistant
  • wound healing
  • surgical site infection
  • escherichia coli
  • acinetobacter baumannii
  • pseudomonas aeruginosa