Genome-wide DNA (hydroxy) methylation reveals the individual epigenetic landscape importance on osteogenic phenotype acquisition in periodontal ligament cells.

Rogério S Ferreira Rahyza Inacio Freire Assis Georgia da Silva Feltran Iasmin Caroline do Rosário Palma Beatriz G Françoso Willian Fernando Zambuzzi Denise Carleto Andia Rodrigo A Foganholi da Silva

Published in: Journal of periodontology (2021)

Epigenetic and transcriptional distinct profiles detected at basal levels among PDLCs were maintained after osteogenic induction. We cannot discard the existence of a complex that represses osteogenesis, suggesting the individual donors' characteristics have significant impact on the osteogenic phenotype acquisition.

Keyphrases

dna methylation
genome wide
mesenchymal stem cells
bone marrow
gene expression
induced apoptosis
cell cycle arrest
transcription factor
single molecule
circulating tumor
single cell
kidney transplantation
oxidative stress
heat shock
endoplasmic reticulum stress
circulating tumor cells