Increased cytomegalovirus immune responses at disease onset are protective in the long-term prognosis of patients with multiple sclerosis.
Manuel Comabella LopezMar TintoreAugusto Sao AvilésPere Carbonell-MirabentSunny MalhotraÀlex RoviraNicolás FissoloJan D LünemannXavier MontalbanPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
These results indicate that elevated immune responses against HCMV at disease onset have protective effects on long-term disability and inflammation disease outcomes. Our data also indicate that increased immune responses against EBV in early phases may influence long-term disease prognosis.