Inflammation and fatigue in early, untreated Parkinson's Disease.

Karen HerlofsonC J HeijnenJ LangeG AlvesO-B TysnesJ H FriedmanC P Fagundes

Published in: Acta neurologica Scandinavica (2018)

Higher serum levels of the inflammatory molecules IL1-Ra and VCAM-1 were associated with higher fatigue levels in patients with newly diagnosed, drug-naïve PD. These findings highlight an altered immune response as a potential contributor to PD-related fatigue, from the earliest clinical stages of the disease.

Keyphrases

immune response
newly diagnosed
sleep quality
oxidative stress
rheumatoid arthritis
toll like receptor
risk assessment
drug induced
disease activity
inflammatory response
cell adhesion