A self-marker-like protein governs hemocyte allorecognition in Halocynthia roretzi.

Masaki EmaTaizo OkadaMiki TakahashiMasato UchiyamaHideo KuboHideaki MoriyamaHitoshi MiyakawaMidori Matsumoto

Published in: Zoological letters (2019)

We generated a CR-inducing monoclonal antibody (mAb11B16B10) that recognized a series of novel membrane proteins (HrSMLP1) in the hemocytes of H. roretzi. The combination of expressed spots of HrSMLP1 distinguishes non-self cells from self cells with respect to CR inducibility. Given that the HrSMLP1 gene is a single gene, it may represent a novel type of self-marker protein with a role in CR.

Keyphrases

monoclonal antibody
induced apoptosis
copy number
genome wide
genome wide identification
cell cycle arrest
gene expression
signaling pathway
amino acid