Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring.
Preeti Dinesh VirwaniGordon QianMatthew S S HsuTommy K K T S PijarnvanitCarman Nga-Man CheungYick Hin ChowLok Kan TangYiu-Hei TseJia-Wen XianShirley Sau-Wing LamCrystal P I LeeChelsea C W LoRoxanna K C LiuTsi-Lok HoBak Yue ChowKin Sum LeungHing Wai TsangEmily Kwun Kwan LoKeith Tsz Suen TungSookja Kim ChungMan Fung YuenSuet Yi LeungPatrick IpIvan Fan-Ngai HungJimmy Chun Yu LouieHani El-NezamiJoshua Wing-Kei HoGary Kui Kai LauPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
GM dysregulation was strongly associated with 24-hour ambulatory blood pressure in women but not men, which may be mediated through propionic acid. Our work suggests that sex differences may be an important consideration while assessing the role of GM in the development and treatment of hypertension.