Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease.

Soichiro KitamuraHitoshi ShimadaFumitoshi NiwaHironobu EndoHitoshi ShinotohKeisuke TakahataManabu KubotaYuhei TakadoShigeki HiranoYasuyuki KimuraMing-Rong ZhangSatoshi KuwabaraTetsuya SuharaMakoto Higuchi

Published in: Journal of neurology, neurosurgery, and psychiatry (2018)

The present findings suggested that tau pathology in OFC may provoke focal neurotoxicity in OFC and the following disruption of the OFC-UNC network, leading to the emergence and progression of apathy in AD.

Keyphrases

cerebrospinal fluid
high glucose
diabetic rats
cognitive decline
endothelial cells