A novel optical probe based on d-penicillamine-functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid.
Paria Pashazadeh-PanahiMohammad HasanzadehReza Eivazzadeh-KeihanPublished in: Journal of molecular recognition : JMR (2020)
In this study, d-penicillamine-functionalized graphene quantum dots (DPA-GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA-GQD respond to Hg2+ , Cu2+ , Au2+ , Ag+ , Co2+ , Zn2+ , and Pb2+ with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg2+ , Cu2+ , Au2+ , Ag+ , Co2+ , Zn2+ , and Pb2+ . In this work, a promising probe for ions monitoring was introduced. Moreover, DPA-GQD probe has been tested in plasma samples. The functionalized DPA-GQDs exhibits great promise as an alternative to previous fluorescent probes for bio-labeling, sensing, and other biomedical applications in aqueous solution.
Keyphrases
- quantum dots
- aqueous solution
- sensitive detection
- living cells
- fluorescent probe
- energy transfer
- single molecule
- loop mediated isothermal amplification
- heavy metals
- endothelial cells
- high intensity
- label free
- small molecule
- high resolution
- room temperature
- machine learning
- big data
- carbon nanotubes
- risk assessment
- deep learning
- high speed
- artificial intelligence
- highly efficient