Exposure to vitamin k antagonists and kidney function decline in patients with atrial fibrillation and chronic kidney disease.
Florian PoschCihan AyHerbert StögerReinhold KreutzJan Beyer-WestendorfPublished in: Research and practice in thrombosis and haemostasis (2019)
In patients with AF and CKD, VKA use is associated with accelerated eGFR decline. Within the limitations of a retrospective analysis, this finding supports the "VKA-renal-calcification hypothesis." However, although statistically significant, the excess loss in eGFR over 5 years with VKA was modest.