Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma.
Benjamin M EllingsonJohn SampsonAchal Singh AchrolManish K AghiKrystof BankiewiczChencai WangMartin BexonSteven BremAndrew J BrennerSajeel ChowdharyJohn R FloydSeunggu HanSantosh KesariDina RandazzoMichael A VogelbaumFrank VrionisMiroslaw ZabekNicholas ButowskiMelissa CoelloNina MerchantFahar MerchantPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
No correlation between radiographic PFS and OS was observed for standard RANO or iRANO, but a correlation was observed between PFS and OS using the mRANO criteria. Also, the iRANO criteria was difficult to implement due to need to confirm progression 3 months after initial progression, censoring more than half the patients.