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Microsatellite instability diagnosis using the fully automated Idylla platform: feasibility study of an in-house rapid molecular testing ancillary to immunohistochemistry in pathology laboratories.

Laura SamaisonMélanie GrallFrédéric StarozArnaud Uguen
Published in: Journal of clinical pathology (2019)
At the era when the determination of MSI/MSS status is becoming important for rapid treatment choices, the Idylla MSI Assay consists of a valuable easy-to-perform diagnostic tool that allows, complementary to MLH1, PMS2, MSH2 and MSH6 immunohistochemistry, the diagnosis of MSI/MSS status in a single day.
Keyphrases
  • high throughput
  • loop mediated isothermal amplification
  • machine learning
  • deep learning
  • genetic diversity
  • sensitive detection
  • tandem mass spectrometry