Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Maha A T ElsebaieZeinab ElsayedPublished in: Archives of gynecology and obstetrics (2017)
While high-quality clinical trial evidence is missing, existing evidence seems to support holding back on radical surgery for selected candidates with well-defined, polypoid, superficial, embryonal cervical/endometrial RMS lesions that could be completely excised with conservative surgery; further local resections with/without radiotherapy are then warranted based on margin status. Experience on the use of neoadjuvant chemotherapy in the conservative management of uterine RMS in adults is very limited, though this approach is golden-standard in pediatrics. A suggested scheme is introduced for the management of uterine RMS.
Keyphrases
- neoadjuvant chemotherapy
- systematic review
- locally advanced
- minimally invasive
- clinical trial
- coronary artery bypass
- end stage renal disease
- squamous cell carcinoma
- newly diagnosed
- small cell lung cancer
- lymph node
- ejection fraction
- sentinel lymph node
- early stage
- meta analyses
- radiation therapy
- endometrial cancer
- rectal cancer
- surgical site infection
- peritoneal dialysis
- coronary artery disease
- childhood cancer
- patient reported outcomes
- open label
- young adults
- phase iii
- phase ii