Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Chuanxia LiuJinhan ZhouShanshan ZhangJi FuYining LiYilong Hao Jian YuanFan TangWeili GeHong HeQian-Ming Chen

Published in: Oral diseases (2023)

The results indicated that MSCs-derived IL-6-promoted tumour invasion and metastasis via JAK-STAT3 signalling. Blockade of this pathway by tocilizumab may be a potential treatment to improve the prognosis and survival rate of patients with OSCC.

Keyphrases

mesenchymal stem cells
cell migration
umbilical cord
rheumatoid arthritis
bone marrow
free survival
juvenile idiopathic arthritis
stem cells
climate change
smoking cessation