Obesity and Transcatheter Aortic Valve Replacement.
Jiyoung SeoAmrin KhawrawalaPawel BorkowskiNikita SinghHarriet AkunorSanjana NagrajDimitrios V AvgerinosDamianos G KokkinidisPublished in: Journal of cardiovascular development and disease (2024)
Amidst an aging population and escalating obesity prevalence, elucidating the impact of obesity on transcatheter aortic valve replacement (TAVR) outcomes becomes paramount. The so-called "obesity paradox"-a term denoting the counterintuitive association of obesity, typically a risk factor for cardiovascular diseases, with improved survival outcomes in TAVR patients relative to their leaner or normal-weight counterparts-merits rigorous examination. This review comprehensively investigates the complex relationship between obesity and the clinical outcomes associated with TAVR, with a specific focus on mortality and periprocedural complications. This study aims to deepen our understanding of obesity's role in TAVR and the underlying mechanisms of the obesity paradox, thereby optimizing management strategies for this patient demographic, tailored to their unique physiological and metabolic profiles.
Keyphrases
- transcatheter aortic valve replacement
- weight loss
- insulin resistance
- metabolic syndrome
- aortic valve
- aortic stenosis
- weight gain
- type diabetes
- high fat diet induced
- ejection fraction
- cardiovascular disease
- skeletal muscle
- physical activity
- newly diagnosed
- venous thromboembolism
- heart failure
- patient reported outcomes
- percutaneous coronary intervention
- cardiovascular events
- acute coronary syndrome
- patient reported
- cardiovascular risk factors