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Heart Failure-Related Iron Deficiency Anemia Pathophysiology and Laboratory Diagnosis.

Silvio Nunes AugustoPieter Martens
Published in: Current heart failure reports (2023)
Recent studies have questioned the current employed definition of iron deficiency in the field of heart failure, as patients with ferritin < 100ng/ml but TSAT > 20% have a better prognosis, no iron deficiency on bone marrow staining, and altered treatment response to ferric carboxymaltose. This review summarizes changes in iron parameters in the setting of heart failure and underscores the importance of a reduced bioavailability of iron documented by a low serum iron or TSAT, irrespective of the presence of anemia.
Keyphrases
  • iron deficiency
  • heart failure
  • bone marrow
  • left ventricular
  • acute heart failure
  • cardiac resynchronization therapy
  • mesenchymal stem cells
  • combination therapy
  • drug induced