Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU.

Ines VerlindenFabian GüizaInge DeresePieter J WoutersKoen JoostenSascha C VerbruggenGreet Van den BergheIlse Vanhorebeek

Published in: Clinical epigenetics (2020)

Critical illness- and early-PN-induced changes in DNA methylation occurred mainly within 3 days. Most abnormalities were at least partially maintained or got worse with longer time in PICU. Interventions targeting aberrant DNA methylation changes should be initiated early.

Keyphrases

dna methylation
genome wide
gene expression
intensive care unit
emergency department
physical activity
copy number
cancer therapy
drug delivery
acute respiratory distress syndrome
extracorporeal membrane oxygenation