Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Timothy R Oâ MearaEtsuro NanishiMarisa E McGrathSoumik BarmanDanica DongCarly DillenManisha MenonHyuk-Soo SeoSirano Dhe-PaganonRobert K ErnstOfer LevyMatthew B FriemanDavid J Dowling

Published in: bioRxiv : the preprint server for biology (2022)

Obesity and type 2 diabetes impair SARS-CoV-2 mRNA vaccine efficacy in a murine model.

Keyphrases

insulin resistance
sars cov
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue
high fat diet
skeletal muscle
respiratory syndrome coronavirus
polycystic ovary syndrome
glycemic control
weight loss
binding protein
weight gain
cardiovascular disease
coronavirus disease