ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy.

Hisanaga NomuraDaiki TsujiKen DemachiNobuo MochizukiHaruki MatsuzawaTomonori YanoHiroyuki DaikoSatoshi FujiiTakashi KojimaKunihiko ItohToshikatsu Kawasaki

Published in: Cancer chemotherapy and pharmacology (2020)

In addition to age and baseline ANC, ABCB1 3435C>T and ABCC2 *+9383C>G were identified as independent predictors for severe neutropenia in esophageal cancer patients treated with DCF chemotherapy.

Keyphrases

chemotherapy induced
locally advanced
rectal cancer
squamous cell carcinoma
genome wide
early onset
radiation therapy
copy number
gene expression
dna methylation
drug induced