Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract.

Panatda SaenkhamJamie Jennings-GeeBraden HansonNancy D KockL Garry AdamsSargurunathan Subashchandrabose

Published in: Diabetes, obesity & metabolism (2020)

Collectively, our results indicate that dapagliflozin-induced hyperglucosuria in non-diabetic female mice leads to increased susceptibility to severe UTI, and bacteraemia of urinary tract origin.

Keyphrases

endothelial cells
urinary tract
high glucose
type diabetes
drug induced
diabetic rats
early onset
high fat diet induced
urinary tract infection
wound healing
oxidative stress
metabolic syndrome
adipose tissue